Patients with type-2 diabetes who are taking the drug Invokana (canagliflozin) should be particularly cautious about symptoms like nausea and vomiting, difficulty breathing, abdominal pain, confusion, and unusual fatigue.
These symptoms may signal a dangerous condition called diabetic ketoacidosis, which can lead to hospitalization, coma, and even death.
What is Invokana?
Invokana has been on the market since March 2013, when the FDA approved it for the treatment of type-2 diabetes. It is one of a new class of drugs called “sodium-glucose co-transporter 2 (SGLT2) inhibitors.
These drugs work to lower blood sugar levels by actually inhibiting the kidneys from absorbing glucose, which causes more of it to be flushed out of the body through urine. Other medications in the same class include Farxiga, Glyxambi, Jardiance, and Xigduo XR.
FDA Warns SGLT2 Inhibitors Can Lead to Ketoacidosis
In May 2015, the Food and Drug Administration (FDA) warned that SGLT2 drugs like Invokana could increase risk of ketoacidosis, a condition in which the body produces too many “ketones.” Ketones are blood acids produced when the body burns fat instead of glucose for fuel.
The condition is often a sign that there is not enough insulin for the body to draw adequate glucose from the blood into the cells, so it turns to fat instead. This is only a problem if high levels of ketones accumulate in the blood — which causes it to become too acidic.
How Does Invokana Cause Ketoacidosis?
Patients with type-1 diabetes are usually the ones most at risk for diabetic ketoacidosis because they often lack sufficient insulin levels. Those with type-2 diabetes typically have enough insulin, but their bodies can’t use it like they should.
In just one year, the Institute for Safe Medication Practices (ISMP) reported that the SGLT2 inhibitor drug Invokana had been named in more adverse event reports as a result of diabetic ketoacidosis than up to 92 percent of all drugs they monitor.
Scientists believe it has something to do with how these drugs interrupt normal kidney function. It is the kidneys, along with the respiratory system, that usually keeps the body’s pH level in balance. They are the organs that flush the ketones out. If there is a buildup of ketones in the body, it must be that the kidneys aren’t able to do their job.
Symptoms of ketoacidosis include those mentioned above: difficulty breathing, nausea and vomiting, abdominal pain, and others. Other early signs that ketoacidosis is occurring may include dry mouth and thirst, frequent urination, high blood sugar levels, and high blood ketone levels.
Diabetic ketoacidosis can lead to serious complications, including:
- Dehydration
- Cerebral edema
- Coma
- Death
Invokana Lawsuits
At this time, attorneys are investigating the possibility of filing Invokana diabetic ketoacidosis lawsuits against Johnson & Johnson, claiming that the drug maker knew or should have known of the high risk of diabetic ketoacidosis associated with its diabetes drug but failed to provide adequate warning in an effort to protect their own profits.
If you or a loved one suffered ketoacidosis or other serious injuries after taking Invokana, an experienced drug injury attorney can help you or your loved one file a Invokana lawsuit.
In general, diabetes medication lawsuits are filed individually by each plaintiff and are not class actions.
Do YOU have a legal claim? Fill out the form on this page now for a free, immediate, and confidential case evaluation. The attorneys who work with Top Class Actions will contact you if you qualify to let you know if an individual lawsuit or class action lawsuit is best for you. Hurry — statutes of limitations may apply.
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If you or a loved one suffered ketoacidosis or kidney failure after taking Invokana, Invokamet, Farxiga, Xigduo XR, Jardiance or Glyxambi, you may have a legal claim. See if you qualify to pursue compensation and join a free diabetes medication class action lawsuit investigation by submitting your information for a free case evaluation.
An attorney will contact you if you qualify to discuss the details of your potential case.
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Invokamet (canagliflozin and metformin)
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